Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SMC6 (Q96SB8) - Overview - Molecular Target Synopsis


SMC6, Structural maintenance of chromosomes protein 6
UniProt Q96SB8

Also Known as SMC6_HUMAN, SMC6, SMC6L1

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). Forms a heterodimer with SMC5 (PubMed:11408570). Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3 (PubMed:18086888). Interacts with NSMCE1 (PubMed:14701739). Interacts with NSMCE2 (PubMed:16055714). Interacts with SLF1 (PubMed:25931565). Interacts with SLF2 (PubMed:25931565). Interacts with RAD18 (PubMed:25931565).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SMC6 is active in the following subcellular-locations: chromosome, nucleus, nucleus speckle, pml body, telomere.
GO terms: SMC6 is active in the following subcellular-locations: chromosome, interchromatin granule, intracellular, nuclear speck, nucleoplasm, nucleus, PML body, sex chromosome, site of double-strand break, Smc5-Smc6 complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SMC6 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, NCI_H522, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-3, TK, A2780

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, K562

(see details)