Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PEBP4 (Q96S96) - Overview - Molecular Target Synopsis

Protein


PEBP4, Phosphatidylethanolamine-binding protein 4
UniProt Q96S96

Also Known as PEBP4_HUMAN, PEBP4, CORK1

Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
227ENSG00000134020ENST00000256404ENSP00000256404Q96S96-1
100ENSG00000134020ENST00000522278ENSP00000429414

Sub-cellular localization


UniProt: PEBP4 is active in the following subcellular-locations: lysosome.
GO terms: PEBP4 is active in the following subcellular-locations: extracellular exosome, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PEBP4 has gain in 0 cell-lines, loss in 12 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, RPMI_8226, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RPMI 2650, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to PEBP4 there are:
10 structures (19 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis