Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RASL10B (Q96S79) - Overview - Molecular Target Synopsis

Protein


RASL10B, Ras-like protein family member 10B
UniProt Q96S79

Also Known as RSLAB_HUMAN, RASL10B

May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure. Interacts with CADPS.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
203ENSG00000141150ENST00000268864ENSP00000268864Q96S79-1

Sub-cellular localization


UniProt: RASL10B is active in the following subcellular-locations: cell membrane.
GO terms: RASL10B is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RASL10B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, CAKI_1, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MS751, MOR, NTERA-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH_RA, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to RASL10B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis