Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TESK2 (Q96S53) - Overview - Molecular Target Synopsis


TESK2, Dual specificity testis-specific protein kinase 2
Enzyme Classification
UniProt Q96S53

Also Known as TESK2_HUMAN, TESK2

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: TESK2 is active in the following subcellular-locations: nucleus.
GO terms: TESK2 is active in the following subcellular-locations: cytoplasm, nuclear body, nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TESK2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, SK_MEL_28, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-257, MEL-HO, SK-MEL-28

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference

TESK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SAOS2, MDAMB231. (see details)

3D Structures

At greater than 35% identity similarity to TESK2 there are:
9 structures (16 chains) solved
9 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TESK2 has been screened with 24 compounds (24 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)