Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TESK2 (Q96S53) - Overview - Molecular Target Synopsis

Protein


TESK2, Dual specificity testis-specific protein kinase 2
Enzyme Classification 2.7.12.1
UniProt Q96S53

Also Known as TESK2_HUMAN, TESK2

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TESK2 is active in the following subcellular-locations: nucleus.
GO terms: TESK2 is active in the following subcellular-locations: cytoplasm, nuclear body, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TESK2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, SK_MEL_28, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-257, MEL-HO, SK-MEL-28

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference


TESK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SAOS2, MDAMB231. (see details)

3D Structures


At greater than 35% identity similarity to TESK2 there are:
9 structures (16 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TESK2 has been screened with 24 compounds (24 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)