TP53RK (Q96S44) - Overview - Molecular Target Synopsis
TP53RK, EKC/KEOPS complex subunit TP53RK
Enzyme Classification 3.6.-.-
Also Known as PRPK_HUMAN, TP53RK, C20orf64, PRPK
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
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UniProt: TP53RK is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TP53RK is active in the following subcellular-locations: cytoplasm, cytosol, EKC/KEOPS complex, nucleoplasm, nucleus.