Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPS6KC1 (Q96S38) - Overview - Molecular Target Synopsis

Protein


RPS6KC1, Ribosomal protein S6 kinase delta-1
Enzyme Classification 2.7.11.1
UniProt Q96S38

Also Known as KS6C1_HUMAN, RPS6KC1, RPK118

May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). Interacts with SPHK1 and phosphatidylinositol 3-phosphate (PubMed:12077123). Interacts (via PX domain) with PRDX3 (PubMed:15750338).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RPS6KC1 is active in the following subcellular-locations: cytoplasm, early endosome, membrane.
GO terms: RPS6KC1 is active in the following subcellular-locations: early endosome, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPS6KC1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, SK_MEL_28, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-150, NCI-H2081, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, K562

(see details)

RNA Interference


RPS6KC1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB231, SJSA1. (see details)

3D Structures


At greater than 50% identity similarity to RPS6KC1 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RPS6KC1 has been screened with 5 compounds (5 bioactivities). (see details)