Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RPS6KC1 (Q96S38) - Overview - Molecular Target Synopsis


RPS6KC1, Ribosomal protein S6 kinase delta-1
Enzyme Classification
UniProt Q96S38

Also Known as KS6C1_HUMAN, RPS6KC1, RPK118

May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). Interacts with SPHK1 and phosphatidylinositol 3-phosphate (PubMed:12077123). Interacts (via PX domain) with PRDX3 (PubMed:15750338).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RPS6KC1 is active in the following subcellular-locations: cytoplasm, early endosome, membrane.
GO terms: RPS6KC1 is active in the following subcellular-locations: early endosome, membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RPS6KC1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, SK_MEL_28, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-150, NCI-H2081, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, K562

(see details)

RNA Interference

RPS6KC1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB231, SJSA1. (see details)

3D Structures

At greater than 50% identity similarity to RPS6KC1 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RPS6KC1 has been screened with 5 compounds (5 bioactivities). (see details)