Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB40C (Q96S21) - Overview - Molecular Target Synopsis

Protein


RAB40C, Ras-related protein Rab-40C
UniProt Q96S21

Also Known as RB40C_HUMAN, RAB40C, RARL, RASL8C

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, ELOB and ELOC.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB40C is active in the following subcellular-locations: cell membrane.
GO terms: RAB40C is active in the following subcellular-locations: Golgi membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB40C has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HCT_15, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H187, VMRC-LCD, MS751

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


At greater than 35% identity similarity to RAB40C there are:
108 structures (240 chains) solved
96 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB40C is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB40C has been screened with compounds ( bioactivities). (see details)