Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRIB1 (Q96RU8) - Overview - Molecular Target Synopsis

Protein


TRIB1, Tribbles homolog 1
UniProt Q96RU8

Also Known as TRIB1_HUMAN, TRIB1, C8FW, GIG2, TRB1

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). Monomer (PubMed:26455797). Interacts (via protein kinase domain) with CEBPA (PubMed:20410507, PubMed:26455797). Interacts with COP1 (PubMed:20410507, PubMed:27041596).

6DC0
TRIBBLES (TRIB1) PSEUDOKINASE FUSED TO CCAAT-ENHANCER BINDING PROTEIN (C/EBPALPHA) DEGRON
RCSB/PDB
Inspect Structure
See all 3D Structures for TRIB1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: TRIB1 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRIB1 has gain in 46 cell-lines, loss in 0 cell-lines and no signal in 958 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, HCT_116, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H716, L-363, ATRFLOX

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)

RNA Interference


TRIB1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BT474, OVISE. (see details)

3D Structures


For TRIB1 there are:
5 structures (14 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRIB1 has been screened with compounds ( bioactivities). (see details)