Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TNFRSF13C (Q96RJ3) - Overview - Molecular Target Synopsis

Protein


TNFRSF13C, Tumor necrosis factor receptor superfamily member 13C
UniProt Q96RJ3

Also Known as TR13C_HUMAN, TNFRSF13C, BAFFR, BR3

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

3V56
12 RESIDUE FRAGMENT OF
BR3 DERIVED PEPTIVE
IN THE STRUCTURE OF
RE-REFINEMENT OF PDB ENTRY 1OSG - COMPLEX BETWEEN BAFF AND A BR3 DERIVED PEPTIDE PRESENTED IN A BETA-HAIRPIN SCAFFOLD - REVEALS AN ADDITONAL COPY OF THE PEPTIDE.
RCSB/PDB
Inspect Structure
See all 3D Structures for TNFRSF13C

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
185Q96RJ3-2
184ENSG00000159958ENST00000291232ENSP00000291232Q96RJ3-1

Sub-cellular localization


UniProt: TNFRSF13C is active in the following subcellular-locations: membrane.
GO terms: TNFRSF13C is active in the following subcellular-locations: external side of plasma membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TNFRSF13C has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, EB2, CCRF-SB

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, GM12878, SK-N-SH

(see details)

3D Structures


For TNFRSF13C there are:
5 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis