Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PASK (Q96RG2) - Overview - Molecular Target Synopsis

Protein


PASK, PAS domain-containing serine/threonine-protein kinase
Enzyme Classification 2.7.11.1
UniProt Q96RG2

Also Known as PASK_HUMAN, PASK, KIAA0135

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

3DLS
CRYSTAL STRUCTURE OF HUMAN PAS KINASE BOUND TO ADP
RCSB/PDB
Inspect Structure
See all 3D Structures for PASK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PASK is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: PASK is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PASK has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, CCRF_CEM, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H345, KARPAS-1106P, MHH-NB-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)

RNA Interference


PASK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: TE14, KNS42. (see details)

3D Structures


For PASK there are:
2 structures (7 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PASK has been screened with 1477 compounds (2327 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)