Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP7 (Q96R05) - Overview - Molecular Target Synopsis

Protein


RBP7, Retinoid-binding protein 7
UniProt Q96R05

Also Known as RET7_HUMAN, RBP7

Intracellular transport of retinol.

6E6K
CRYSTAL STRUCTURE OF HUMAN CELLULAR RETINOL-BINDING PROTEIN 4 IN COMPLEX WITH ABNORMAL-CANNABIDIOL (ABN-CBD)
RCSB/PDB
Inspect Structure
See all 3D Structures for RBP7

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
134ENSG00000162444ENST00000294435ENSP00000294435Q96R05-1
59ENSG00000162444ENST00000315901ENSP00000324228

Sub-cellular localization


UniProt: RBP7 is active in the following subcellular-locations: cytoplasm.
GO terms: RBP7 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBP7 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, HCT_116, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GP2d, MDA-MB-157, GP5d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RBP7 there are:
3 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RBP7 has been screened with compounds ( bioactivities). (see details)