Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PSKH2 (Q96QS6) - Overview - Molecular Target Synopsis

Protein


PSKH2, Serine/threonine-protein kinase H2
Enzyme Classification 2.7.11.1
UniProt Q96QS6

Also Known as KPSH2_HUMAN, PSKH2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
385ENSG00000147613ENST00000276616ENSP00000276616Q96QS6-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project PSKH2 has gain in 14 cell-lines, loss in 3 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


PSKH2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: KPD, UW479. (see details)

3D Structures


At greater than 35% identity similarity to PSKH2 there are:
159 structures (235 chains) solved
124 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

PSKH2 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2YAB_A, 2YAB_B, 4Y5Q_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PSKH2 has been screened with compounds ( bioactivities). (see details)