Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PSKH2 (Q96QS6) - Overview - Molecular Target Synopsis


PSKH2, Serine/threonine-protein kinase H2
Enzyme Classification
UniProt Q96QS6

Also Known as KPSH2_HUMAN, PSKH2

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation

In COSMIC - Cell Lines Project PSKH2 has gain in 14 cell-lines, loss in 3 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

PSKH2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: KPD, UW479. (see details)

3D Structures

At greater than 35% identity similarity to PSKH2 there are:
159 structures (235 chains) solved
124 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

PSKH2 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PSKH2 has been screened with compounds ( bioactivities). (see details)