Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A13 (Q96QE2) - Overview - Molecular Target Synopsis

Protein


SLC2A13, Proton myo-inositol cotransporter
UniProt Q96QE2

Also Known as MYCT_HUMAN, SLC2A13

H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
648ENSG00000151229ENST00000280871ENSP00000280871Q96QE2-1
357ENSG00000151229ENST00000380858ENSP00000370239

Sub-cellular localization


UniProt: SLC2A13 is active in the following subcellular-locations: membrane.
GO terms: SLC2A13 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A13 has gain in 6 cell-lines, loss in 5 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, NCI_H460, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H460, OCI-LY-3, JHH-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to SLC2A13 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis