Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CDK15 (Q96Q40) - Overview - Molecular Target Synopsis


CDK15, Cyclin-dependent kinase 15
Enzyme Classification
UniProt Q96Q40

Also Known as CDK15_HUMAN, CDK15, ALS2CR7, PFTK2

Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: CDK15 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CDK15 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 786-O, SNU-387, SW 1573

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, SK-N-SH, NHLF

(see details)

RNA Interference

CDK15 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVTOKO, HCH1. (see details)

3D Structures

At greater than 50% identity similarity to CDK15 there are:
16 structures (29 chains) solved
11 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CDK15 has been screened with 120 compounds (166 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (6 bioactivities). (see details)