Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LMTK3 (Q96Q04) - Overview - Molecular Target Synopsis

Protein


LMTK3, Serine/threonine-protein kinase LMTK3
Enzyme Classification 2.7.11.1
UniProt Q96Q04

Also Known as LMTK3_HUMAN, LMTK3, KIAA1883, TYKLM3

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1489ENSG00000142235ENST00000270238ENSP00000270238
1460ENSG00000142235ENST00000600059ENSP00000472020Q96Q04-1

Sub-cellular localization


UniProt: LMTK3 is active in the following subcellular-locations: axon, cell projection, dendrite, golgi apparatus membrane, membrane.
GO terms: LMTK3 is active in the following subcellular-locations: axon, dendrite, Golgi membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LMTK3 has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G-402, SUM 52PE, DMS 53

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

RNA Interference


LMTK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL120, SF188. (see details)

3D Structures


At greater than 35% identity similarity to LMTK3 there are:
88 structures (148 chains) solved
74 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LMTK3 has been screened with compounds ( bioactivities). (see details)