LMTK3 (Q96Q04) - Overview - Molecular Target Synopsis
LMTK3, Serine/threonine-protein kinase LMTK3
Enzyme Classification 220.127.116.11
Also Known as LMTK3_HUMAN, LMTK3, KIAA1883, TYKLM3
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity). Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).
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UniProt: LMTK3 is active in the following subcellular-locations: axon, cell projection, dendrite, golgi apparatus membrane, membrane.
GO terms: LMTK3 is active in the following subcellular-locations: axon, dendrite, Golgi membrane, integral component of membrane.