Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TSSK3 (Q96PN8) - Overview - Molecular Target Synopsis


TSSK3, Testis-specific serine/threonine-protein kinase 3
Enzyme Classification
UniProt Q96PN8

Also Known as TSSK3_HUMAN, TSSK3, SPOGA3, STK22C

May be involved in a signaling pathway during male germ cell development or mature sperm function.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: TSSK3 is active in the following subcellular-locations: cytoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TSSK3 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HS578T, TK_10, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

TSSK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SUM44, HCC202. (see details)

3D Structures

At greater than 35% identity similarity to TSSK3 there are:
131 structures (216 chains) solved
97 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TSSK3 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TSSK3 has been screened with 7 compounds (7 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)