Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TSSK3 (Q96PN8) - Overview - Molecular Target Synopsis

Protein


TSSK3, Testis-specific serine/threonine-protein kinase 3
Enzyme Classification 2.7.11.1
UniProt Q96PN8

Also Known as TSSK3_HUMAN, TSSK3, SPOGA3, STK22C

May be involved in a signaling pathway during male germ cell development or mature sperm function.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
268ENSG00000162526ENST00000373534ENSP00000362634Q96PN8-1
35ENSG00000162526ENST00000574315ENSP00000459187

Sub-cellular localization


GO terms: TSSK3 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TSSK3 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, TK_10, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


TSSK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SUM44, HCC202. (see details)

3D Structures


At greater than 35% identity similarity to TSSK3 there are:
131 structures (216 chains) solved
97 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TSSK3 is solved in complex with the approved drug(s):

XIN/NINTEDANIB (5MAF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TSSK3 has been screened with compounds ( bioactivities). (see details)