Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY10 (Q96PN6) - Overview - Molecular Target Synopsis

Protein


ADCY10, Adenylate cyclase type 10
Enzyme Classification 4.6.1.1
UniProt Q96PN6

Also Known as ADCYA_HUMAN, ADCY10, SAC

Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).

5IV3
CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH ALPHA,BETA-METHYLENEADENOSINE-5'-TRIPHOSPHATE AND THE ALLOSTERIC INHIBITOR LRE1
RCSB/PDB
Inspect Structure
See all 3D Structures for ADCY10

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCY10 is active in the following subcellular-locations: cell membrane, cell projection, cilium, cytoplasm, cytoskeleton, mitochondrion, nucleus, perinuclear region.
GO terms: ADCY10 is active in the following subcellular-locations: apical part of cell, basal part of cell, cilium, cytoplasm, cytoskeleton, cytosol, dendrite, growth cone, mitochondrion, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY10 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, KM12, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ADCY10 there are:
30 structures (30 chains) solved
24 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ADCY10 is solved in complex with the approved drug(s):

B1T/BITHIONOL (5D0R_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY10 has been screened with 4 compounds (4 bioactivities). (see details)