Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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RPRD1A (Q96P16) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria3


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4JXT_A Regulation of nuclear pre-mRNA domain-containing protein 1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 67.9 35.4 Yes No
2 empty 2.18 64.3 20.9 No No
3 empty 2.21 59 14.2 No No
4 empty 1.66 72.2 9.8 No No
5 empty 2.53 56.5 11.4 No No
6 empty 1.89 66.1 9.8 No No
7 empty 2.07 61.2 8.8 No No
8 empty 2.28 55.4 9.8 No No
9 empty 1.87 71.1 5.3 No No
10 empty 2.37 57.7 9.3 No No
4NAC_B Regulation of nuclear pre-mRNA domain-containing protein 1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 63.1 37.4 Yes No
2 empty 2.16 64 14.5 No No
3 empty 2.17 64.6 18.5 No No
4 empty 2.5 65.9 12.5 No No
5 empty 2.36 74.2 6.4 No No
6 empty 2.16 57.9 11.1 No No
7 empty 1.89 59.5 11 No No
8 empty 2.39 73.9 5.5 No No
9 empty 3.05 59.8 6.5 No No
10 empty 2.6 91.1 0 Yes No
4NAC_A Regulation of nuclear pre-mRNA domain-containing protein 1A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 65.4 41.3 Yes No
2 empty 2.46 59.6 18.8 No No
3 empty 2.13 59.5 20.8 No No
4 empty 2.28 66.4 12.1 No No
5 empty 2.1 66.5 12.3 No No
6 empty 2.24 57.4 15.5 No No
7 empty 2.29 66.2 9.8 No No
8 empty 2.42 57.3 11.5 No No
9 empty 2.63 60.2 9.2 No No
10 empty 2.33 64.1 6.1 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RPRD1A is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 48.98
Druggability for Cancer Therapeutics: 48.36
Druggability for Other Therapeutics: 13.40
Cancer-Associated
Cancer-associated percentile : 63.50
Network Articulation Point
Is RPRD1A critical for communication in the network?


Detailed Graph Legend:Help