Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPRD1A (Q96P16) - Overview - Molecular Target Synopsis

Protein


RPRD1A, Regulation of nuclear pre-mRNA domain-containing protein 1A
UniProt Q96P16

Also Known as RPR1A_HUMAN, RPRD1A, P15RS

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. May form a heterodimer with RPRD1B (PubMed:24997600). Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats) (PubMed:22231121, PubMed:24997600, PubMed:24399136).

4NAC
CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF P15RS
RCSB/PDB
Inspect Structure
See all 3D Structures for RPRD1A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RPRD1A is active in the following subcellular-locations: nucleoplasm, RNA polymerase II.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPRD1A has gain in 6 cell-lines, loss in 10 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: DU_145, MCF7, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-510, NCI-H209, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

3D Structures


For RPRD1A there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis