Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NSUN5 (Q96P11) - Overview - Molecular Target Synopsis

Protein


NSUN5, Probable 28S rRNA (cytosine-C(5))-methyltransferase
Enzyme Classification 2.1.1.-
UniProt Q96P11

Also Known as NSUN5_HUMAN, NSUN5, NSUN5A, WBSCR20, WBSCR20A

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA.

2B9E
HUMAN NSUN5 PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for NSUN5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: NSUN5 is active in the following subcellular-locations: nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NSUN5 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, K_562, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 480, LN-18, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, K562

(see details)

3D Structures


For NSUN5 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis