Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAMK1G (Q96NX5) - Overview - Molecular Target Synopsis

Protein


CAMK1G, Calcium/calmodulin-dependent protein kinase type 1G
Enzyme Classification 2.7.11.17
UniProt Q96NX5

Also Known as KCC1G_HUMAN, CAMK1G, CLICK3, VWS1

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1.

2JAM
CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
RCSB/PDB
Inspect Structure
See all 3D Structures for CAMK1G

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
476ENSG00000008118ENST00000361322, ENST00000009105ENSP00000354861, ENSP00000009105Q96NX5-1
460Q96NX5-2
245ENSG00000008118ENST00000423146ENSP00000392173

Sub-cellular localization


UniProt: CAMK1G is active in the following subcellular-locations: cell membrane, cytoplasm, golgi apparatus membrane.
GO terms: CAMK1G is active in the following subcellular-locations: calcium- and calmodulin-dependent protein kinase complex, Golgi membrane, neuron projection, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAMK1G has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, HOP_92, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-673, NCI-H2052, ES-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


CAMK1G was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PL5, BT20. (see details)

3D Structures


For CAMK1G there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CAMK1G has been screened with 263 compounds (327 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)