Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AMDHD1 (Q96NU7) - Overview - Molecular Target Synopsis

Protein


AMDHD1, Probable imidazolonepropionase
Enzyme Classification 3.5.2.7
UniProt Q96NU7

Also Known as HUTI_HUMAN, AMDHD1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: AMDHD1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AMDHD1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, KM12, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1623, HCC1143, HCC-15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to AMDHD1 there are:
6 structures (10 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis