SLC46A1 (Q96NT5) - Overview - Molecular Target Synopsis
SLC46A1, Proton-coupled folate transporter
Also Known as PCFT_HUMAN, SLC46A1, HCP1, PCFT
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Monomer.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: SLC46A1 is active in the following subcellular-locations: apical cell membrane, cytoplasm.
GO terms: SLC46A1 is active in the following subcellular-locations: apical plasma membrane, brush border membrane, cell surface, cytoplasm, integral component of membrane, plasma membrane.