Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC46A1 (Q96NT5) - Overview - Molecular Target Synopsis

Protein


SLC46A1, Proton-coupled folate transporter
UniProt Q96NT5

Also Known as PCFT_HUMAN, SLC46A1, HCP1, PCFT

Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Monomer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC46A1 is active in the following subcellular-locations: apical cell membrane, cytoplasm.
GO terms: SLC46A1 is active in the following subcellular-locations: apical plasma membrane, brush border membrane, cell surface, cytoplasm, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC46A1 has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, ACHN, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C2BBe1, ZR-75-30, AGS

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC46A1 has been screened with 24 compounds (83 bioactivities), 14 compounds have bioactivities that show binding affinity of <= 500nM (22 bioactivities). (see details)