Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AIFM3 (Q96NN9) - Overview - Molecular Target Synopsis

Protein


AIFM3, Apoptosis-inducing factor 3
Enzyme Classification 1.-.-.-
UniProt Q96NN9

Also Known as AIFM3_HUMAN, AIFM3, AIFL

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.

5O9V
8 RESIDUE FRAGMENT OF
APOPTOSIS-INDUCING FACTOR 3
IN THE STRUCTURE OF
HSNMT1 IN COMPLEX WITH COA AND MYRISTOYLATED-GGCFSKPK OCTAPEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for AIFM3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AIFM3 is active in the following subcellular-locations: mitochondrion.
GO terms: AIFM3 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, mitochondrial inner membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AIFM3 has gain in 15 cell-lines, loss in 2 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HOP_62, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GP2d, SNU-C1, HT-55

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For AIFM3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis