Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RSKR (Q96LW2) - Overview - Molecular Target Synopsis

Protein


RSKR, Ribosomal protein S6 kinase-related protein
Enzyme Classification 2.7.11.1
UniProt Q96LW2

Also Known as KS6R_HUMAN, RSKR, SGK494

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
274Q96LW2-1
171ENSG00000258472ENST00000584196, ENST00000481916, ENST00000534850ENSP00000464466, ENSP00000436369, ENSP00000437573Q96LW2-2

Gene Copy Number Variation


In COSMIC - Cell Lines Project RSKR has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


At greater than 35% identity similarity to RSKR there are:
14 structures (22 chains) solved
14 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RSKR has been screened with compounds ( bioactivities). (see details)