Molecular Target Synopsis
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PRMT6 (Q96LA8) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed21
Chains with at least one site assessed as druggable using the strict criteria21
Chains with at least one site assessed as druggable using the relaxed criteria21


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4HC4_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 69.5 38.9 Yes Yes
2 empty 2.21 63.4 31.9 No No
3 empty 2.14 64.6 32.6 No No
4 empty 2.6 66.4 21.7 No No
5 empty 2.47 60.8 14.6 No No
6 empty 1.9 66.8 24.3 No No
7 empty 1.87 59.1 15.1 No No
8 empty 1.64 62.8 11 No No
9 empty 2.02 69.2 13.2 No No
10 empty 1.99 59.2 14.5 No No
6P7I_C Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 79.7 33.7 Yes Yes
2 empty 1.83 70.4 29.6 No No
3 empty 2.12 64.1 33.6 No No
4 empty 2.25 64.8 22.6 No No
5 empty 2.05 63.2 23.2 No No
6 empty 2.33 61.6 16.4 No No
7 empty 2.32 62.3 23.7 No No
8 empty 2.3 67.8 14.4 No No
9 empty 2.66 64.1 14.4 No No
10 empty 1.71 63.5 13.7 No No
4QPP_C Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 73.3 35.3 Yes Yes
2 empty 1.89 57.9 18.8 No No
3 empty 2.52 66.8 11.2 No No
4 empty 1.83 62.3 15.1 No No
5 empty 2.06 64.2 13.2 No No
6 empty 2.16 67.6 12.5 No No
7 empty 1.94 59.2 14 No No
8 empty 2.06 54.7 14.4 No No
9 bound 1.98 63.4 14.1 No No
10 empty 1.92 62.4 12.2 No No
5E8R_B Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 73.7 35.5 Yes Yes
2 empty 2.41 60.6 27.6 No No
3 empty 1.91 62.4 19.6 No No
4 empty 2.03 67.3 23.2 No No
5 empty 1.95 77.2 13.6 No No
6 empty 1.71 61.2 20.1 No No
7 empty 1.9 70.6 12.3 No No
8 empty 2.39 59.5 14.8 No No
9 empty 2.35 62 12.3 No No
10 empty 2.03 63 11.7 No No
5EGS_B Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 76.9 36.1 Yes Yes
2 empty 1.96 69.1 32.9 No No
3 empty 2.1 58.9 27.4 No No
4 empty 2.19 66.6 19.2 No No
5 empty 2.03 61.9 23.1 No No
6 empty 1.72 60.7 15.7 No No
7 empty 1.95 59.7 17.6 No No
8 empty 2.1 66.4 16.3 No No
9 empty 2.24 58.6 13 No No
10 empty 2.77 66.3 12.7 No No
4QPP_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 73.2 35.4 Yes Yes
2 empty 2.6 65.1 14.3 No No
3 empty 1.86 59.7 19.4 No No
4 empty 1.84 65.8 16.5 No No
5 empty 1.86 65.4 11.7 No No
6 empty 2.15 67.8 12.5 No No
7 empty 2.03 62.6 12.8 No No
8 empty 2.07 54 14.4 No No
9 empty 2.05 59.6 12.3 No No
10 empty 2.33 58.1 14.8 No No
4Y2H_B Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 67.1 36.2 Yes Yes
2 bound 1.84 75.4 39.2 No No
3 empty 2.45 66.1 30.7 No No
4 empty 2.03 64.1 23.7 No No
5 empty 2.31 59.7 26.5 No No
6 empty 2.23 63.5 15.2 No No
7 empty 2.16 63.7 19.4 No No
8 empty 2.41 59.9 15.5 No No
9 empty 2 68.2 13.2 No No
10 empty 1.56 65.2 12.2 No No
5WCF_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 73.7 26.6 Yes No
2 bound 1.09 98.8 0 Yes Yes
3 empty 2.67 69.2 21.9 No No
4 empty 1.9 65.8 19 No No
5 empty 1.98 63 27.5 No No
6 empty 2.24 63.4 22.6 No No
7 empty 2.3 61.5 24.4 No No
8 empty 2.01 65.2 17.7 No No
9 empty 2.07 68.9 13.3 No No
10 empty 2.13 61 13.3 No No
4Y30_B Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 66.4 29.6 Yes Yes
2 bound 1.73 75.9 39 Yes No
3 empty 2.31 67.4 20.2 No No
4 empty 1.99 56.9 23.2 No No
5 empty 2.4 64.1 14.2 No No
6 empty 2.01 60.2 18.9 No No
7 empty 2.11 62.4 16.9 No No
8 empty 1.67 63 18.6 No No
9 empty 2.42 60.4 17.2 No No
10 empty 2.17 66.9 11.4 No No
5EGS_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 76 36 Yes Yes
2 bound 1.87 72.1 35.5 No No
3 empty 2.51 64.1 30.9 No No
4 empty 2.19 64.1 27.3 No No
5 empty 1.92 61.4 20.9 No No
6 empty 2.32 61.1 16.6 No No
7 empty 2.13 56.3 24.3 No No
8 empty 2.22 65.2 17.4 No No
9 empty 2 63 16.6 No No
10 empty 1.81 63.1 21.2 No No
4QPP_B Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 73.4 35 Yes Yes
2 empty 2.51 63.6 13.7 No No
3 empty 2.08 56.8 21.7 No No
4 empty 2.13 67.3 14.3 No No
5 empty 2.24 59.6 14.7 No No
6 empty 1.98 53.6 14 No No
7 empty 1.81 67.7 14.7 No No
8 empty 1.97 60.1 14.7 No No
9 empty 2.04 63.1 14.1 No No
10 empty 1.74 57.4 14.4 No No
6P7I_D Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 68 39.7 Yes Yes
2 bound 1.74 76.9 36.9 Yes No
3 empty 2.18 65 25.6 No No
4 empty 2.02 60 20 No No
5 empty 2.1 59.9 16 No No
6 empty 2.14 61.6 16.4 No No
7 empty 2.72 62.4 18.5 No No
8 empty 1.87 58.8 13.6 No No
9 empty 1.55 62.6 15.3 No No
10 empty 2.75 64.4 16.6 No No
4Y2H_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 80.5 28.1 Yes Yes
2 empty 1.99 68.1 35.2 No No
3 empty 2.16 61.2 33.8 No No
4 empty 2.31 65.9 23.4 No No
5 empty 2.41 59.8 21 No No
6 empty 2.19 59.2 29.6 No No
7 empty 1.88 59.9 25.4 No No
8 empty 2.28 63.6 15.2 No No
9 empty 2.11 71.6 10.7 No No
10 empty 2.81 59.1 13 No No
5HZM_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 71.2 38.2 Yes Yes
2 empty 2.2 64.7 21.8 No No
3 empty 2.25 63.6 28.5 No No
4 empty 2.66 64.8 23.8 No No
5 empty 2.06 60 22 No No
6 empty 1.94 62.1 19.6 No No
7 empty 2.15 63.1 15 No No
8 empty 2.01 71.9 12.8 No No
9 empty 2.14 58.3 15.1 No No
10 empty 2.02 64.6 11.1 No No
4QQK_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 73.4 34.9 Yes Yes
2 empty 2.12 61.6 25.6 No No
3 bound 2.67 66.4 22.8 No No
4 empty 2.34 68.8 20.8 No No
5 empty 2.36 61.4 16.2 No No
6 empty 1.72 62.1 16.8 No No
7 empty 2.03 61.3 19 No No
8 empty 1.79 61.1 17.1 No No
9 empty 1.56 64.6 12 No No
10 empty 2.09 69.6 11.7 No No
5E8R_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 77.1 34.6 Yes Yes
2 empty 1.62 71.5 30.2 Yes No
3 empty 2.09 62.5 23.4 No No
4 empty 1.84 63.1 24 No No
5 empty 2.01 69.9 16.2 No No
6 empty 2.18 61.1 14.7 No No
7 empty 2.37 59.2 21.2 No No
8 empty 1.48 63.7 14.7 No No
9 empty 1.96 68.7 12.4 No No
10 empty 2.1 62.2 14.9 No No
5EGS_C Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 80.4 37 Yes Yes
2 bound 1.8 70.2 36.3 No No
3 empty 2.16 64.8 24.6 No No
4 empty 2.15 63.1 23.2 No No
5 empty 2.34 61.5 19.2 No No
6 empty 2.12 70.3 15.1 No No
7 empty 1.98 61.9 23.7 No No
8 empty 1.98 61.9 21.7 No No
9 empty 2.41 64.1 15.5 No No
10 empty 1.78 59 16.8 No No
4Y30_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 75.5 35.1 Yes Yes
2 empty 2.04 65.7 35.1 No No
3 empty 2.55 65.2 34.3 No No
4 empty 1.91 63.2 24.9 No No
5 empty 2.25 69.7 17.9 No No
6 empty 1.91 59.3 22.6 No No
7 empty 1.83 60.1 23.9 No No
8 empty 2 63.5 17.5 No No
9 empty 2.39 65.8 13 No No
10 empty 1.98 69.9 12.7 No No
6P7I_A Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 76.9 35.1 Yes Yes
2 empty 1.8 70.7 35.2 No No
3 empty 2 63.9 33.2 No No
4 empty 2.24 59.2 21 No No
5 empty 2.31 68.9 17.6 No No
6 empty 2.35 66.7 15.6 No No
7 empty 1.98 62.6 20.7 No No
8 empty 1.72 62.1 19.8 No No
9 empty 1.63 60.9 13.3 No No
10 empty 2.12 65.3 11.6 No No
5EGS_D Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 74.9 37.8 Yes Yes
2 empty 1.9 69.3 32.7 No No
3 empty 2.16 63.9 26.3 No No
4 empty 2.07 65.5 24.8 No No
5 empty 2.79 65.6 22.7 No No
6 empty 2.32 60.6 13.2 No No
7 empty 1.97 60.1 21.6 No No
8 empty 1.5 64.5 13.9 No No
9 empty 1.91 57.6 15.8 No No
10 empty 1.97 60.8 14.4 No No
6P7I_B Protein arginine N-methyltransferase 6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 75.4 37.9 Yes Yes
2 empty 1.88 66.3 35.6 No No
3 empty 2.11 70.2 18.2 No No
4 empty 2.16 61.3 26.7 No No
5 empty 1.99 61.5 26.9 No No
6 empty 1.98 61.2 18.4 No No
7 empty 2.07 58.8 14.1 No No
8 empty 2.19 67.7 16.7 No No
9 empty 1.63 63.4 13.5 No No
10 empty 2.62 64.9 13.9 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PRMT6 is involved in 90 interactions in the network.


Druggability
Overall Druggability Percentile: 24.29
Druggability for Cancer Therapeutics: 71.99
Druggability for Other Therapeutics: 48.83
Cancer-Associated
Cancer-associated percentile : 90.94
Network Articulation Point
Is PRMT6 critical for communication in the network?


Detailed Graph Legend:Help