Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALPK3 (Q96L96) - Overview - Molecular Target Synopsis

Protein


ALPK3, Alpha-protein kinase 3
Enzyme Classification 2.7.11.1
UniProt Q96L96

Also Known as ALPK3_HUMAN, ALPK3, KIAA1330, MAK

Involved in cardiomyocyte differentiation.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1907ENSG00000136383ENST00000258888ENSP00000258888Q96L96-1

Sub-cellular localization


UniProt: ALPK3 is active in the following subcellular-locations: nucleus.
GO terms: ALPK3 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALPK3 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, SNB_19, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WiDr, NCI-H1155, HT-29

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HUVEC, SK-N-SH

(see details)

RNA Interference


ALPK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SUM149, CAL120. (see details)

3D Structures


At greater than 35% identity similarity to ALPK3 there are:
1 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALPK3 has been screened with compounds ( bioactivities). (see details)