Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOV (Q96L33) - Overview - Molecular Target Synopsis

Protein


RHOV, Rho-related GTP-binding protein RhoV
UniProt Q96L33

Also Known as RHOV_HUMAN, RHOV, ARHV, WRCH2

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. Interacts with PAK2.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
236ENSG00000104140ENST00000220507ENSP00000220507Q96L33-1

Sub-cellular localization


UniProt: RHOV is active in the following subcellular-locations: cell membrane, endosome membrane.
GO terms: RHOV is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, cytosol, endosome membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOV has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, T47D, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EKVX, HCC2302, NCI-H1568

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, A549, GM12878

(see details)

3D Structures


At greater than 50% identity similarity to RHOV there are:
90 structures (155 chains) solved
65 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

RHOV is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2WKP_A, 2WKQ_A, 2WKR_A),
AMP/ADENOSINE PHOSPHATE (4ITR_C, 4ITR_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOV has been screened with compounds ( bioactivities). (see details)