Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FAM210B (Q96KR6) - Overview - Molecular Target Synopsis

Protein


FAM210B, Protein FAM210B, mitochondrial
UniProt Q96KR6

Also Known as F210B_HUMAN, FAM210B, C20orf108

Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
192ENSG00000124098ENST00000371384ENSP00000360437Q96KR6-1
58ENSG00000124098ENST00000437418ENSP00000389768

Sub-cellular localization


UniProt: FAM210B is active in the following subcellular-locations: mitochondrion, mitochondrion outer membrane.
GO terms: FAM210B is active in the following subcellular-locations: integral component of membrane, intrinsic component of membrane, mitochondrial outer membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FAM210B has gain in 13 cell-lines, loss in 0 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CPC-N, EVSA-T, HT-144

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)