Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL5B (Q96KC2) - Overview - Molecular Target Synopsis

Protein


ARL5B, ADP-ribosylation factor-like protein 5B
UniProt Q96KC2

Also Known as ARL5B_HUMAN, ARL5B, ARL8

Binds and exchanges GTP and GDP.

1YZG
STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 8
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL5B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
179ENSG00000165997ENST00000377275ENSP00000366487Q9D4P0-1, Q96KC2-1

Sub-cellular localization


GO terms: ARL5B is active in the following subcellular-locations: cytoplasm, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL5B has gain in 3 cell-lines, loss in 6 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, NCI_H322M, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C2BBe1, DMS 53, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, AG445, NHLF

(see details)

3D Structures


For ARL5B there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL5B has been screened with compounds ( bioactivities). (see details)