Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PBK (Q96KB5) - Overview - Molecular Target Synopsis

Protein


PBK, Lymphokine-activated killer T-cell-originated protein kinase
Enzyme Classification 2.7.12.2
UniProt Q96KB5

Also Known as TOPK_HUMAN, PBK, TOPK

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.

5J0A
CRYSTAL STRUCTURE OF PDZ-BINDING KINASE
RCSB/PDB
Inspect Structure
See all 3D Structures for PBK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: PBK is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PBK has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, MDA_MB_435, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 699, G124, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, MCF-7

(see details)

RNA Interference


PBK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H2342, MCF12A. (see details)

3D Structures


For PBK there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PBK has been screened with 316 compounds (323 bioactivities), 47 compounds have bioactivities that show binding affinity of <= 500nM (47 bioactivities). (see details)