PBK (Q96KB5) - Overview - Molecular Target Synopsis
PBK, Lymphokine-activated killer T-cell-originated protein kinase
Enzyme Classification 18.104.22.168
Also Known as TOPK_HUMAN, PBK, TOPK
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.
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