Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RITA1 (Q96K30) - Overview - Molecular Target Synopsis

Protein


RITA1, RBPJ-interacting and tubulin-associated protein 1
UniProt Q96K30

Also Known as RITA1_HUMAN, RITA1, C12orf52, RITA

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. Interacts with RBPJ/RBPSUH.

5EG6
16 RESIDUE FRAGMENT OF
HRITA
IN THE STRUCTURE OF
CSL-RITA COMPLEX BOUND TO DNA
RCSB/PDB
Inspect Structure
See all 3D Structures for RITA1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RITA1 is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center, nucleus.
GO terms: RITA1 is active in the following subcellular-locations: centrosome, cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RITA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ML-2, NU-DUL-1, NCI-H2804

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, SK-N-SH

(see details)

3D Structures


For RITA1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis