Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RADIL (Q96JH8) - Overview - Molecular Target Synopsis

Protein


RADIL, Ras-associating and dilute domain-containing protein
UniProt Q96JH8

Also Known as RADIL_HUMAN, RADIL, KIAA1849

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304). Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).

3EC8
THE CRYSTAL STRUCTURE OF THE RA DOMAIN OF FLJ10324 (RADIL)
RCSB/PDB
Inspect Structure
See all 3D Structures for RADIL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RADIL is active in the following subcellular-locations: microtubule, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RADIL has gain in 8 cell-lines, loss in 2 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, SK_MEL_5, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 792, MHH-NB-11, KELLY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RADIL there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RADIL has been screened with compounds ( bioactivities). (see details)