Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC12 (Q96J65) - Overview - Molecular Target Synopsis

Protein


ABCC12, Multidrug resistance-associated protein 9
UniProt Q96J65

Also Known as MRP9_HUMAN, ABCC12, MRP9

Probable transporter.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCC12 is active in the following subcellular-locations: membrane.
GO terms: ABCC12 is active in the following subcellular-locations: integral component of membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC12 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCC12 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC12 has been screened with compounds ( bioactivities). (see details)