Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CPB2 (Q96IY4) - Overview - Molecular Target Synopsis

Protein


CPB2, Carboxypeptidase B2
Enzyme Classification 3.4.17.20
UniProt Q96IY4

Also Known as CBPB2_HUMAN, CPB2

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

5HVG
CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-A204)
RCSB/PDB
Inspect Structure
See all 3D Structures for CPB2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
423ENSG00000080618ENST00000181383ENSP00000181383Q96IY4-1
360ENSG00000080618ENST00000439329ENSP00000400714
360Q96IY4-2

Sub-cellular localization


UniProt: CPB2 is active in the following subcellular-locations: secreted.
GO terms: CPB2 is active in the following subcellular-locations: cell, extracellular exosome, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CPB2 has gain in 1 cell-lines, loss in 7 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HOP_92, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, C3A, HuH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HepG2, SK-N-SH, NHLF

(see details)

3D Structures


For CPB2 there are:
8 structures (15 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CPB2 has been screened with 272 compounds (316 bioactivities), 164 compounds have bioactivities that show binding affinity of <= 500nM (185 bioactivities). (see details)