Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD14B (Q96IU4) - Overview - Molecular Target Synopsis

Protein


ABHD14B, Protein ABHD14B
Enzyme Classification 3.-.-.-
UniProt Q96IU4

Also Known as ABHEB_HUMAN, ABHD14B, CIB

Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription. May interact with TAF1.

1IMJ
CRYSTAL STRUCTURE OF THE HUMAN CCG1/TAFII250-INTERACTING FACTOR B (CIB)
RCSB/PDB
Inspect Structure
See all 3D Structures for ABHD14B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABHD14B is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: ABHD14B is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD14B has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, MDA_MB_435, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 1463, SKM-1, HM7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, HSMM

(see details)

3D Structures


For ABHD14B there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis