Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DIRAS2 (Q96HU8) - Overview - Molecular Target Synopsis

Protein


DIRAS2, GTP-binding protein Di-Ras2
UniProt Q96HU8

Also Known as DIRA2_HUMAN, DIRAS2

Displays low GTPase activity and exists predominantly in the GTP-bound form.

2ERX
CRYSTAL STRUCTURE OF DIRAS2 IN COMPLEX WITH GDP AND INORGANIC PHOSPHATE
RCSB/PDB
Inspect Structure
See all 3D Structures for DIRAS2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
211ENSG00000165023ENST00000375765ENSP00000364919
199Q96HU8-1

Sub-cellular localization


UniProt: DIRAS2 is active in the following subcellular-locations: cell membrane.
GO terms: DIRAS2 is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DIRAS2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, RXF_393, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-70, HCC1482, NIH:OVCAR-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For DIRAS2 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DIRAS2 has been screened with compounds ( bioactivities). (see details)