Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FMC1 (Q96HJ9) - Overview - Molecular Target Synopsis

Protein


FMC1, Protein FMC1 homolog
UniProt Q96HJ9

Also Known as FMC1_HUMAN, FMC1, C7orf55

Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) (PubMed:28719601). Interacts with ATPAF2 (PubMed:28719601).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
458ENSG00000269955ENST00000541515ENSP00000440222Q96HJ9-2
113ENSG00000164898ENST00000297534ENSP00000297534Q96HJ9-1

Sub-cellular localization


UniProt: FMC1 is active in the following subcellular-locations: mitochondrion.
GO terms: FMC1 is active in the following subcellular-locations: mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FMC1 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)