Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACY3 (Q96HD9) - Overview - Molecular Target Synopsis

Protein


ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
Enzyme Classification 3.5.1.114
UniProt Q96HD9

Also Known as ACY3_HUMAN, ACY3, ASPA2

Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids. Exists as a mixture of homodimers and homotetramer, both catalytically active.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
319ENSG00000132744ENST00000255082ENSP00000255082Q96HD9-1
198ENSG00000132744ENST00000529256ENSP00000434270

Sub-cellular localization


UniProt: ACY3 is active in the following subcellular-locations: apical cell membrane, cytoplasm.
GO terms: ACY3 is active in the following subcellular-locations: apical plasma membrane, cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACY3 has gain in 12 cell-lines, loss in 0 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HCT_15, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 205, COLO 206F, KARPAS-620

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ACY3 there are:
4 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis