Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD17A (Q96GS6) - Overview - Molecular Target Synopsis

Protein


ABHD17A, Alpha/beta hydrolase domain-containing protein 17A
Enzyme Classification 3.1.2.22
UniProt Q96GS6

Also Known as AB17A_HUMAN, ABHD17A, C19orf27, FAM108A1

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABHD17A is active in the following subcellular-locations: cell junction, cell membrane, cell projection, dendritic spine, endosome membrane, postsynaptic cell membrane, postsynaptic density, synapse.
GO terms: ABHD17A is active in the following subcellular-locations: anchored component of postsynaptic density membrane, anchored component of postsynaptic recycling endosome membrane, cell junction, dendritic spine, endosome membrane, glutamatergic synapse, membrane, plasma membrane, recycling endosome membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD17A has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1155, DU 145, G120

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)


Screening and Chemistry


ABHD17A has been screened with compounds ( bioactivities). (see details)