Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSBG1 (Q96GR2) - Overview - Molecular Target Synopsis

Protein


ACSBG1, Long-chain-fatty-acid--CoA ligase ACSBG1
Enzyme Classification 6.2.1.3
UniProt Q96GR2

Also Known as ACBG1_HUMAN, ACSBG1, BGM, KIAA0631, LPD

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSBG1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, microsome.
GO terms: ACSBG1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSBG1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, MCF7, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KU812, SET-2, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACSBG1 there are:
4 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis