Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TRMT2B (Q96GJ1) - Overview - Molecular Target Synopsis


TRMT2B, tRNA (uracil(54)-C(5))-methyltransferase homolog
Enzyme Classification
UniProt Q96GJ1

Also Known as TRM2_HUMAN, TRMT2B, CXorf34

Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.

Isoforms / Transcripts (Protein Coding)

Gene Copy Number Variation

In COSMIC - Cell Lines Project TRMT2B has gain in 1 cell-lines, loss in 28 cell-lines and no signal in 976 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H460, HOP_62, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H460, HCC366, HCC2270

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, MCF-7, HUVEC

(see details)