Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRMT2B (Q96GJ1) - Overview - Molecular Target Synopsis

Protein


TRMT2B, tRNA (uracil(54)-C(5))-methyltransferase homolog
Enzyme Classification 2.1.1.35
UniProt Q96GJ1

Also Known as TRM2_HUMAN, TRMT2B, CXorf34

Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project TRMT2B has gain in 1 cell-lines, loss in 28 cell-lines and no signal in 976 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, HOP_62, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H460, HCC366, HCC2270

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, MCF-7, HUVEC

(see details)