Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LTV1 (Q96GA3) - Overview - Molecular Target Synopsis

Protein


LTV1, Protein LTV1 homolog
UniProt Q96GA3

Also Known as LTV1_HUMAN, LTV1, C6orf93


6G18
CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - STATE C
RCSB/PDB
Inspect Structure
See all 3D Structures for LTV1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
475ENSG00000135521ENST00000367576ENSP00000356548Q5R8B2-1, Q96GA3-1

Sub-cellular localization


GO terms: LTV1 is active in the following subcellular-locations: cytosol, EGO complex, late endosome membrane, nucleoplasm, nucleus, preribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LTV1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-7, NCI-H1299, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, MCF-7

(see details)

3D Structures


For LTV1 there are:
5 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis