Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EEF2KMT (Q96G04) - Overview - Molecular Target Synopsis

Protein


EEF2KMT, Protein-lysine N-methyltransferase EEF2KMT
Enzyme Classification 2.1.1.-
UniProt Q96G04

Also Known as EF2KT_HUMAN, EEF2KMT, FAM86A

Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. Interacts with FAM86B2 and FAM86C1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EEF2KMT is active in the following subcellular-locations: cytoplasm.
GO terms: EEF2KMT is active in the following subcellular-locations: cytoplasm, cytosol, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EEF2KMT has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RPMI 8226, LS1034, NCI-H1651

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, HMEC

(see details)