Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRMT61A (Q96FX7) - Overview - Molecular Target Synopsis

Protein


TRMT61A, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Enzyme Classification 2.1.1.220
UniProt Q96FX7

Also Known as TRM61_HUMAN, TRMT61A, C14orf172, TRM61

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.

5CCB
CRYSTAL STRUCTURE OF HUMAN M1A58 METHYLTRANSFERASE IN A COMPLEX WITH TRNA3LYS AND SAH
RCSB/PDB
Inspect Structure
See all 3D Structures for TRMT61A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
289ENSG00000166166ENST00000389749ENSP00000374399Q96FX7-1
193ENSG00000166166ENST00000299202ENSP00000299202

Sub-cellular localization


UniProt: TRMT61A is active in the following subcellular-locations: nucleus.
GO terms: TRMT61A is active in the following subcellular-locations: nucleoplasm, nucleus, tRNA (m1A) methyltransferase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRMT61A has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, MCF7, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, Ca Ski, SF268

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HeLa-S3

(see details)

3D Structures


For TRMT61A there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis