NEIL1 (Q96FI4) - Overview - Molecular Target Synopsis
NEIL1, Endonuclease 8-like 1
Enzyme Classification 3.2.2.-
Also Known as NEIL1_HUMAN, NEIL1
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|390||ENSG00000140398||ENST00000355059, ENST00000564784, ENST00000569035||ENSP00000347170, ENSP00000457352, ENSP00000455730||Q96FI4-1|
UniProt: NEIL1 is active in the following subcellular-locations: centrosome, chromosome, cytoplasm, cytoskeleton, microtubule organizing center, nucleus.
GO terms: NEIL1 is active in the following subcellular-locations: chromosome, cytoplasm, microtubule organizing center, nucleoplasm, nucleus.