Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NEIL1 (Q96FI4) - Overview - Molecular Target Synopsis

Protein


NEIL1, Endonuclease 8-like 1
Enzyme Classification 3.2.2.-
UniProt Q96FI4

Also Known as NEIL1_HUMAN, NEIL1

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

5ITT
CRYSTAL STRUCTURE OF HUMAN NEIL1 BOUND TO DUPLEX DNA CONTAINING THF
RCSB/PDB
Inspect Structure
See all 3D Structures for NEIL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NEIL1 is active in the following subcellular-locations: centrosome, chromosome, cytoplasm, cytoskeleton, microtubule organizing center, nucleus.
GO terms: NEIL1 is active in the following subcellular-locations: chromosome, cytoplasm, microtubule organizing center, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NEIL1 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, MDA_N, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: YMB-1, YMB-1-E, GA-10

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, CD20-positive B cell

(see details)

RNA Interference


NEIL1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For NEIL1 there are:
8 structures (18 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis