Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALG14 (Q96F25) - Overview - Molecular Target Synopsis

Protein


ALG14, UDP-N-acetylglucosamine transferase subunit ALG14 homolog
UniProt Q96F25

Also Known as ALG14_HUMAN, ALG14

May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. Heterodimer with ALG13 isoform 2 to form a functional enzyme.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
216ENSG00000172339ENST00000370205ENSP00000359224Q96F25-1

Sub-cellular localization


UniProt: ALG14 is active in the following subcellular-locations: endoplasmic reticulum membrane, nucleus membrane.
GO terms: ALG14 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, nuclear membrane, UDP-N-acetylglucosamine transferase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALG14 has gain in 7 cell-lines, loss in 2 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, HCC12, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)