Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SAT2 (Q96F10) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2Q4V_A Diamine acetyltransferase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 67.8 43 Yes Yes
2 empty 2.16 62.4 23.4 No No
3 empty 2.52 57.1 13.8 No No
4 empty 2.42 64.4 11 No No
5 empty 2.2 60.4 8.1 No No
6 empty 2.5 69.1 12.8 No No
7 empty 2.43 66.2 8.4 No No
8 empty 2.4 69.8 10.2 No No
9 empty 2.26 48.3 8.8 No No
10 empty 2.86 55.1 7.3 No No
2BEI_B Diamine acetyltransferase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 69.4 44.8 Yes Yes
2 empty 1.8 66.3 9.3 No No
3 empty 2 66 9.6 No No
4 empty 2.8 65.1 9.5 No No
5 empty 3.45 62.3 8.3 No No
6 empty 2.94 61.3 6.2 No No
7 empty 2.9 64.8 6.7 No No
8 empty 2.27 54.5 6.1 No No
9 empty .88 16.8 7.6 No No
10 empty 2.88 47.3 6.2 No No
2BEI_A Diamine acetyltransferase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 67.9 43.1 Yes Yes
2 empty 2.37 58.5 23.1 No No
3 empty 2.03 66 7.6 No No
4 empty 2.34 55.1 9.9 No No
5 empty 1.83 54.6 8.7 No No
6 empty 2.4 67.2 7 No No
7 empty 2.01 56.9 8 No No
8 empty 2.29 68.7 7.9 No No
9 empty 1.78 57 5.6 No No
10 empty 2.87 54.7 8.4 No No
2Q4V_B Diamine acetyltransferase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 67.9 45.1 Yes Yes
2 empty 1.83 63.6 9.5 No No
3 empty 1.98 64.6 10 No No
4 empty 2.81 60.2 11.9 No No
5 empty 2.71 66.4 8 No No
6 empty 3.19 64.1 7.1 No No
7 empty 2.19 54.8 6.7 No No
8 empty 2.78 66.7 7.4 No No
9 empty 2.79 55.4 8.1 No No
10 empty 3.56 53.9 8.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria5
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2BEI_B (4142705) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT (Homo Multimer) 1.84Å Yes Yes
2BEI_A (128379) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT 1.84Å Yes Yes
2BEI_B (128380) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT 1.84Å Yes Yes
2BEI_A (4142705) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT (Homo Multimer) 1.84Å Yes Yes
2Q4V_A (4067404) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT (Homo Multimer) 1.84Å Yes Yes
2Q4V_B (4067404) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT (Homo Multimer) 1.84Å Yes Yes
2Q4V_A (139878) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT 1.84Å Yes No
2Q4V_B (139879) Diamine acetyltransferase 2 Acyl-CoA N-acyltransferases (Nat), Acyl-CoA N-acyltransferases (Nat), N-acetyl transferase NAT 1.84Å Yes Yes
Ligand-based Druggability Score: -1.6
Ligand-based Druggability Score Percentile: 63%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


SAT2 is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 70.68
Druggability for Cancer Therapeutics: 73.47
Druggability for Other Therapeutics: 39.81
Cancer-Associated
Cancer-associated percentile : 78.28
Network Articulation Point
Is SAT2 critical for communication in the network?


Detailed Graph Legend:Help