Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SAT2 (Q96F10) - Overview - Molecular Target Synopsis

Protein


SAT2, Diamine acetyltransferase 2
Enzyme Classification 2.3.1.57
UniProt Q96F10

Also Known as SAT2_HUMAN, SAT2, SSAT2

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine. Homodimer.

2Q4V
ENSEMBLE REFINEMENT OF THE PROTEIN CRYSTAL STRUCTURE OF THIALYSINE N- ACETYLTRANSFERASE (SSAT2) FROM HOMO SAPIENS
RCSB/PDB
Inspect Structure
See all 3D Structures for SAT2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
170ENSG00000141504ENST00000269298ENSP00000269298Q96F10-1
136ENSG00000141504ENST00000573566ENSP00000458385

Sub-cellular localization


UniProt: SAT2 is active in the following subcellular-locations: cytoplasm.
GO terms: SAT2 is active in the following subcellular-locations: cytoplasm, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SAT2 has gain in 1 cell-lines, loss in 10 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, A498, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-436, Hs 746T, MDST8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For SAT2 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SAT2 has been screened with compounds ( bioactivities). (see details)