Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADAT3 (Q96EY9) - Overview - Molecular Target Synopsis

Protein


ADAT3, Probable inactive tRNA-specific adenosine deaminase-like protein 3
UniProt Q96EY9

Also Known as ADAT3_HUMAN, ADAT3, TAD3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ADAT3 is active in the following subcellular-locations: nucleoplasm, tRNA-specific adenosine-34 deaminase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADAT3 has gain in 0 cell-lines, loss in 5 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, SK_MEL_28, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, LXFL529, LNCAP

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to ADAT3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis